Phase 2a trial to complete enrollment 1H 2022. Because such statements deal with future events and are based on our current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Pliant Therapeutics could differ materially from those described in or implied by the statements in this press release. Founded by a group of seasoned experts . These forward-looking statements are subject to risks and uncertainties, including those related to the development and commercialization of our product candidates, including any delays in our ongoing or planned preclinical or clinical trials, the impact of the ongoing COVID-19 pandemic on our business, operations, clinical supply and plans, the risks inherent in the drug development process, the risks regarding the accuracy of our estimates of expenses and timing of development, our capital requirements and the need for additional financing, and our ability to obtain and maintain intellectual property protection for our product candidates. Pliant Therapeutics is a clinical stage biopharmaceutical company focused on discovering and developing novel therapies for the treatment of fibrosis. Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Investor and Media Contact:Christopher KeenanVice President, Investor Relations and Corporate CommunicationsPliant Therapeutics, [email protected]. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar to meet the unmet medical needs of physicians, patients and families impacted by . Images are analyzed for regions of high fibrotic activity, which are then evaluated for target engagement. "Anyone interested in American history as well as the future contours of our economy will find Dr. Atkinson's analyses a guide to the past and a provocative challenge for the future. , you can buy Pliant Therapeutics Inc stock in any dollar amount, or any other fund or stock you know on Stash. Founded by Third Rock Ventures with . COVID-19 Preparedness The Company continues to develop and maintain policies and procedures to enable us to operate safely and productively during the COVID-19 pandemic. In addition to clinical stage programs, Pliant currently has two preclinical programs targeting oncology and muscular dystrophies. Pliant has also developed PLN-1474, a small-molecule selective inhibitor of αvß1 for the treatment of nonalcoholic steatohepatitis, or NASH with liver fibrosis, which Pliant has transferred to Novartis pursuant to its development partnership. These and additional risks are discussed in the sections titled "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations" in our Annual Report on Form 10-K filed with the SEC on March 16, 2021, as updated by our Quarterly Report on Form 10-Q filed with the SEC on May 10, 2021 and our Quarterly Report on Form 10-Q for the quarter ended June 30, 2021, which we are filing with the SEC today, each available on the SEC's website at www.sec.gov. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar to meet the unmet medical needs of physicians, patients and families impacted by . Found insideForrest Stuart gives us a new framework for understanding life in criminalized communities throughout America. Because such statements deal with future events and are based on our current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Pliant Therapeutics could differ materially from those described in or implied by the statements in this press release. Pliant Therapeutics is a clinical stage biopharmaceutical company focused on discovering and developing novel therapies for the treatment of fibrosis. on November 30, 2020. Pliant Therapeutics is a clinical stage biotechnology company targeting the key biological pathways driving fibrosis. PLN-74809 has received Orphan Drug Designation from the U.S. Food and Drug Administration for both IPF and PSC. Pliant's lead product candidate, PLN-74809, is an oral small-molecule dual selective inhibitor of avß6 and avß1 integrins that is in development for the treatment of idiopathic pulmonary fibrosis, or IPF, and primary sclerosing cholangitis, or PSC. In addition to clinical stage programs, Pliant currently has two preclinical programs targeting oncology and muscular dystrophies. Pliant Corporation is a leading producer of value-added film and flexible packaging products. "We believe the high target engagement levels seen after the administration of just a single dose illustrate the potential of PLN-74809 to show a potent anti-fibrotic effect in our longer-term clinical trials," said Éric Lefebvre, M.D., Chief Medical Officer of Pliant Therapeutics. Investor and Media Contact:Christopher Keenan By harnessing the therapeutic potential of integrin biology and TGF-β modulation, the company aims to prevent or reverse fibrosis to address the needs of patients. Found insideThis comprehensive book helps you understand the unique physiologic and psychosocial changes that affect the elderly adult. The Company has experienced delays in clinical trial operations which have impacted, and may further impact the expected timing of data readouts. By leveraging its powerful product discovery engine, Pliant's mission is to halt progression and reverse disease, and ultimately to restore organ function. Pliant Therapeutics, Inc. is a clinical stage biopharmaceutical company. By leveraging its powerful product discovery engine, Pliant's mission is to halt progression and reverse disease, and ultimately to restore organ function. Found inside – Page iIn order to achieve the revolutionary new defense capabilities offered by materials science and engineering, innovative management to reduce the risks associated with translating research results will be needed along with the R&D. While ... Found insideThe essays explore the diplomatic negotiations and disputes in key international fora, such as the World Trade Organization, the World Health Organization and the World Intellectual Property Organization. "We closed a successful IPO, took important steps in advancing our clinical programs across four indications, and further strengthened our leadership team. The ongoing Phase 2a open-label PET imaging clinical trial is designed to evaluate αvβ6 target engagement levels achieved by PLN-74809 when administered across single-doses of 60 mg, 120 mg, 240 mg or 320 mg in IPF patients. Series A redeemable convertible preferred stock, respectively; aggregate liquidation preference of. Series C redeemable convertible preferred stock, 0 shares and 44,000,000 shares authorized at, http://www.prnewswire.com/news-releases/pliant-therapeutics-provides-corporate-update-and-reports-third-quarter-2020-financial-results-301170058.html. - Single dose administration of PLN-74809 achieved αvβ6 target engagement up to 98% in the lungs of IPF patients, - All doses achieved target engagement above the threshold for predicted anti-fibrotic activity, with an observed dose-response relationship- PLN-74809 reached highly fibrotic regions of the lung and was bound to αvβ6 in IPF patients - Data provide insight into potential anti-fibrotic activity of PLN-74809 at the doses being evaluated in the ongoing Phase 2a INTEGRIS-IPF trial, - Company to host conference call and webcast today at 8:00 a.m. These statements include those regarding our product candidates, including their development and therapeutic potential, the advancement of our clinical and preclinical pipeline, including the timing, enrollment and results of our clinical trials, the impact of the ongoing COVID-19 pandemic on our business, operations, clinical trials, clinical supply and plans, our collaboration with Novartis for PLN-1474 and the intended benefits of such collaborations, and our financial position and cash runway. Pliant is currently recruiting Phase 2a trials of PLN-74809 in the lead indications of IPF and PSC. Pliant Therapeutics is a public, clinical stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. For additional information about Pliant, visit www.pliantrx.com and follow us on Twitter, LinkedIn, Facebook, and YouTube. For additional information about Pliant Therapeutics, visit www.pliantrx.com and follow us on Twitter, LinkedIn, Facebook, and YouTube. Pliant's lead product candidate, PLN-74809, is an oral small-molecule dual selective inhibitor of avß6 and avß1 integrins that it is developing for the treatment of idiopathic pulmonary fibrosis, or IPF, and primary sclerosing cholangitis, or PSC. Vice President, Investor Relations and Corporate CommunicationsPliant Therapeutics, [email protected], Condensed Statements of Operations and Comprehensive Loss, (In thousands, except number of shares and per share amounts), Accretion to redemption value and cumulative dividends on, Net loss attributable to common stockholders. (RTTNews) - The lockup period of Pliant Therapeutics Inc. (PLRX) ends today, i.e. These magnificent beasts are here to spark your creativity. Preferred stock, $0.0001 par value; 10,000,000 shares and 0 shares   authorized at September 30, 2020 and December 31, 2019, respectively;   0 shares issued and outstanding at September 30, 2020   and December 31, 2019; Series A redeemable convertible preferred stock, $0.0001 par value;   0 and 56,000,000 shares authorized at September 30, 2020   and December 31, 2019, respectively; 0 and 56,000,000 shares   issued and outstanding, at September 30, 2020 and December 31, 2019,   respectively; aggregate liquidation preference of $0 and $62,468 at September 30, 2020 and December 31, 2019, respectively; Series B redeemable convertible preferred stock, $0.0001 par value;   0 shares and 49,501,221 shares authorized at September 30, 2020 and December 31, 2019, respectively; 0 shares and 49,501,221 shares   issued and outstanding at September 30, 2020 and December 31, 2019,   respectively; aggregate liquidation preference of $0 and $75,860   at September 30, 2020 and December 31, 2019, respectively; Series C redeemable convertible preferred stock, $0.0001 par value;   0 shares and 44,000,000 shares authorized at September 30, 2020 and December 31, 2019, respectively; 0 shares and 26,360,745 shares   issued and outstanding at September 30, 2020 and December 31, 2019,   respectively; aggregate liquidation preference of $0 and $47,947   at September 30, 2020 and December 31, 2019,  respectively; Common stock, $0.0001 par value; 300,000,000 and 181,000,000 shares authorized   at September 30, 2020 and December 31, 2019; and 35,465,715 and 1,846,024 shares   issued and outstanding at September 30, 2020 and December 31, 2019, respectively; Total liabilities, redeemable convertible preferred stock and stockholders' equity Pliant Therapeutics is a biotechnology company unraveling and targeting the key biological pathways driving fibrosis. PLN-74809 has received Orphan Drug Designation from the U.S. Food and Drug Administration for both IPF and PSC. PLN-1474 is currently undergoing a Phase 1 trial. The aim of this book is to provide research ethics committee members with a resource that focuses on research ethics issues in Africa. This suggests a possible upside of 176.7% from the stock's current price. Pliant Therapeutics is a public, clinical stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Found inside – Page 1The world is awash in data. This volume of data will continue to increase. In the pharmaceutical industry, much of this data explosion has happened around biomarker data. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived ... Pliant is a clinical-stage biopharmaceutical company, with two lead assets namely PLN-74809 . PLN-74809 has received Orphan Drug Designation from the U.S. Food and Drug Administration for both IPF and PSC. Patients undergo a PET scan prior to dosing and at four hours post-dose to evaluate target αvβ6 specific engagement. Pliant Therapeutics is a clinical stage biotechnology company unraveling and targeting the key biological pathways driving fibrosis. We cannot succeed on this journey without you. Pliant continues to develop policies and procedures to enable the Company to operate safely and productively during the COVID-19 pandemic. These are the injuries that result from repeated motions, vibrations, and forces placed on human bodies while performing various job actions. They are extremely common and costly problems for people and companies. Pliant Therapeutics is a public, clinical stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. It focuses in treating fibrosis by inhibiting integrin-mediated activation of transforming growth factor beta (TGF-ß). This volume comprises 12 chapters authored by Covington & Burling lawyers. Pliant Therapeutics (NASDAQ: PLRX) has filed to raise $86.25 million in an IPO of its common stock, according to an S-1 registration statement. It is focused on discovering and developing novel therapies for the treatment of fibrosis. For additional information about Pliant Therapeutics, visit www.pliantrx.com and follow us on Twitter, LinkedIn, Facebook and YouTube. Net loss of $22.8 million as compared to $17.0 million for the prior-year quarter due an overall increase in expense associated with our research and development programs as well as personnel-related costs. Pliant Therapeutics is a public, clinical stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. SOUTH SAN FRANCISCO, Calif., Nov. 10, 2020 /PRNewswire/ -- Pliant Therapeutics, Inc. (Nasdaq: PLRX) (the Company), a clinical stage biotechnology company focused on discovering and developing novel therapeutics for the treatment of fibrosis, today provided a corporate update and reported third quarter 2020 financial results. By leveraging our powerful product discovery engine, Pliant is developing novel therapeutics that seek to halt progression of fibrotic diseases — ultimately, preserving organ function. These and additional risks are discussed in the sections titled "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations" in our Annual Report on Form 10-K filed with the SEC on March 16, 2021, as updated by our Quarterly Report on Form 10-Q for the quarter ended June 30, 2021, each available on the SEC's website at www.sec.gov. By leveraging its powerful product discovery engine, Pliant's mission is to halt progression and reverse disease, and ultimately to restore organ function. "PLN-74809 continues to demonstrate a favorable safety profile as additional dose cohorts from the single and multiple ascending dose Phase 1a trial show PLN-74809 to be generally well tolerated at all dose levels tested, with a predictable pharmacokinetic profile similar to previous dose cohorts.". The book demonstrates the global scenario of the acceptance and demand for these products and explores the regulatory hurdles and claim substantiation of these foods and dietary supplements, as well as addressing the intricate aspects of ... Found insideThe impact of neoliberal governance on indigenous peoples in liberal settler states may be both enabling and constraining. This book is distinctive in drawing comparisons between three such states—Australia, Canada and New Zealand. Pliant Therapeutics Reports Positive Interim Results from Phase 2a PET Imaging Clinical Trial in Patients with Idiopathic Pulmonary Fibrosis, Pliant Therapeutics Announces Webcast to Present Interim Clinical Data from Ongoing Phase 2a PET Trial of PLN-74809 in Patients with Idiopathic Pulmonary Fibrosis, Pliant Therapeutics to Participate in Upcoming Investor Conferences, Pliant Therapeutics Provides Corporate Update and Reports Second Quarter 2021 Financial Results, Pliant Therapeutics to Participate in the BTIG Biotechnology Conference, View All Pliant's approach has the potential to significantly advance the treatment of fibrosis. The Company will host a conference call and webcast at 8:00 a.m. Pliant's lead product candidate, PLN-74809, is an oral small-molecule dual selective inhibitor of avß6 and avß1 integrins that it is developing for the treatment of idiopathic pulmonary. Target engagement of 50% was previously established in a Phase 1b trial as the threshold for predicted clinical anti-fibrotic effect. Pliant's second product candidate, PLN-1474, is a small-molecule selective inhibitor of avß1 for the treatment of liver fibrosis associated with nonalcoholic steatohepatitis, or NASH, which Pliant has partnered with Novartis. Forward-Looking Statements Series B redeemable convertible preferred stock, 0 shares and 49,501,221 shares authorized at. Pliant Therapeutics is a clinical stage biotechnology company unraveling and targeting the key biological pathways driving fibrosis. Because such statements deal with future events and are based on our current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Pliant Therapeutics could differ materially from those described in or implied by the statements in this press release. by The Fold, Keep your ear to the ground with our FREE newsletter including our watch list, weekly review and daily updates. Pliant's lead . (Deficit). About Pliant Therapeutics, Inc. The increase was due primarily to employee related expenses and higher costs related to the advancement of several programs and ongoing Phase 1/2 clinical trials. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar to meet the unmet medical needs of physicians, patients and families impacted by . Data from four patients given the anti-fibrosis candidate suggest . SOUTH SAN FRANCISCO, Calif., May 05, 2021 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical stage biotechnology company focused on discovering and developing novel therapeutics for the treatment of fibrosis, today announced its participation in the 2021 RBC Capital Markets Global Healthcare Conference to be held virtually from May 18 -19, 2021. Across four dose levels, all patients achieved greater than 50% target engagement after a single dose of PLN-74809. PLN-74809 has received Orphan Drug Designation from the U.S. Food and Drug Administration for both IPF and PSC. These forward-looking statements are subject to risks and uncertainties, including those related to the development and commercialization of our product candidates, including any delays in our ongoing or planned preclinical or clinical trials, the ongoing nature of our Phase 2a PET trial and the possibility that the preliminary data will not be predictive of full data from this trial, the possibility that results from this trial will not be predictive of future clinical outcomes, the impact of the ongoing COVID-19 pandemic on our business, operations, clinical supply and plans, the risks inherent in the drug development process, the risks regarding the accuracy of our estimates of expenses and timing of development, our capital requirements and the need for additional financing, and our ability to obtain and maintain intellectual property protection for our product candidates. Pliant Therapeutics is a public, clinical stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Phase 2a PET positive interim data results released September 7, 2021. "Driven by our progress throughout the second quarter, enrollment continues to be on track for our Phase 2a trials of PLN-74809 in IPF and PSC with strong advancement in our development stage oncology and DMD programs," said Bernard Coulie, M.D., Ph.D., President and Chief Executive Officer of Pliant Therapeutics. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar to meet the unmet medical needs of physicians, patients and families impacted by . Investor and Media Contact:Christopher KeenanVice President, Investor Relations and Corporate CommunicationsPliant Therapeutics, [email protected], Pliant Therapeutics, Inc.Condensed Statements of Operations(Unaudited)(In thousands, except number of shares and per share amounts), Pliant Therapeutics, Inc.Condensed Balance Sheets(Unaudited)(In thousands). $25. "Reflecting back on the first three quarters of 2020, I'm proud of the progress we've made despite the challenges related to the COVID-19 pandemic," said Bernard Coulie, M.D., Ph.D., Chief Executive Officer and President of Pliant Therapeutics. Pliant Therapeutics is a public, clinical stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Pliant is a clinical-stage biopharmaceutical company, with two lead assets namely PLN-74809 . The company, currently valued at $699.77M, closed the recent trade at $21.17 per share which meant it gained $1.85 on the day or 9.58% during that session. Estimates by analysts give the company expected earnings per share (EPS) of -$0.67, with the EPS growth for the year raised at -$2.69 for 2021 and -$3.26 for next year. Pliant's lead product candidate, PLN-74809, is an oral small-molecule dual selective inhibitor of αvß6 and αvß1 integrins that is in development for . Found inside – Page vWith the aid of a series of instructive case studies, this book presents the characteristic high-resolution computed tomography (HRCT) findings seen in the group of disorders referred to as interstitial lung disease. Pliant has also developed PLN-1474, a small molecule selective inhibitor of αvß1 for the treatment of nonalcoholic steatohepatitis, or NASH with liver fibrosis, which Pliant has transferred to Novartis pursuant to our development partnership. Pliant Therapeutics is a clinical stage biopharmaceutical company focused on discovering and developing novel therapies for the treatment of fibrosis. About Pliant Therapeutics, Inc. Pliant is a clinical stage biopharmaceutical company focused on discovering and developing novel therapies for the treatment of fibrotic and related diseases . SOUTH SAN FRANCISCO, Calif., Sept. 03, 2021 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (NASDAQ:PLRX), a clinical stage biotechnology company focused on discovering and developing novel therapeutics for the treatment of fibrosis, today announced that the Company plans to issue a pre-market press release and conduct a conference call and webcast on Tuesday, September 7, 2021, to discuss . Pliant Therapeutics is a public, clinical stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Words such as "may," "will," "expect," "anticipate," "estimate," "intend," and similar expressions (as well as other words or expressions referencing future events, conditions, or circumstances) are intended to identify forward-looking statements. The link to the webcast of the conference call will be posted in the Events & Presentations section of the Company's website. ET on Tuesday, September 7th to discuss this update. Phase 1 trial has completed - well tolerated with no dose- or treatment-limiting toxicities or severe/serious adverse events observed. In addition to clinical stage programs, Pliant currently has two preclinical programs targeting oncology and muscular dystrophies. Pliant Therapeutics is a company focused on discovering, developing, and commercializing treatments for fibrotic diseases. (RTTNews) - The lockup period of Pliant Therapeutics Inc. (PLRX) ends today, i.e. Pliant Therapeutics Biotechnology South San Francisco, California 3,637 followers We are transforming the lives of patients by developing best-in-class treatments for fibrotic diseases. Pliant is currently recruiting Phase 2a trials of PLN-74809 for the treatment of IPF and PSC. Te practice of intensive care medicine is at the very forefront of titration of treatment andmonitoringresponse. Te substrateofthiscareisthe criticallyill patientwho,by defnition, is at the limits of his or her physiologic reserve. It offers product discovery engine. Pliant Therapeutics is actively using 33 technologies for its website, according to BuiltWith. Four IPF patients were administered six single doses of PLN-74809 across 60 mg, 120 mg, 240 mg or 320 mg, generating a total of six post-dose scans. Michel Foucault examines the archeology of madness in the West from 1500 to 1800 - from the late Middle Ages, when insanity was still considered part of everyday life and fools and lunatics walked the streets freely, to the time when such ... Beginning with fundamental chapters on the psychological, environmental, and social aspects of aging, the book approaches patient care from a holistic point of view. The Company continues to work closely with clinical sites to continue site initiation and operation activities in compliance with study protocols while observing government and institutional guidelines. For additional information about Pliant Therapeutics, visit www.pliantrx.com and follow us on Twitter, LinkedIn, and Facebook. Sep. 7, 2021, 12:07 PM. Preferred stock, respectively ; aggregate liquidation preference of the increase was due to higher personnel-related and professional services.. 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